CHARACTERIZATION OF THE T3 DOSE-RESPONSE PROFILE OF TR! AND TR" STEADY-STATE mRNA LEVELS IN TAIL TISSUE, AND INVESTIGATION POTENTIAL THYROID AXIS DISRUPTION FROM LOW-DOSE EXPOSURE TO THE POLYCYCLIC MUSK GALAXOLIDETM IN PREMETAMORPHIC RANA CATESBEIANA TADPOLES
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3'-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2(-/-)) become hypothermic due to impaired...
متن کاملIdentical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families.
Generalized resistance to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid hormone. 28 different point mutations in the human thyroid hormone receptor beta (TR beta) gene have been associated with GRTH. These mutations are clustered in two regions of the T3 binding domain of the TR beta (codons 310-347 and 417-453). We now report point mutations in ...
متن کاملImmunohistochemical localization of thyroid hormone nuclear receptors in human hair follicles and in vitro effect of L-triiodothyronine on cultured cells of hair follicles and skin.
To investigate the cellular basis of the action of thyroid hormone on hair follicles, we studied the immunohistochemical localization of thyroid hormone receptors (TRs) in human scalp skin using a mouse monoclonal antibody, TR alpha 1 (C4) against TRs. Immunoreactive TRs were detected in the nuclei of the outer root sheath cells (ORSCs), dermal papilla cells (DPCs), fibrous sheath cells of hair...
متن کاملThyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta.
Thyroid hormone disrupting compounds in water sources is a concern. Thyroid hormone (TH) agonist and antagonist activities of water sources from the Yangtze River, Huaihe River, Taihu Lake and ground water in the Yangtze River Delta region were evaluated by use of a TH reporter gene assay based on the green monkey kidney fibroblast (CV-1). While weak TH receptor (TR) agonist potency was observe...
متن کاملA Low Power Imaging Alternative to bSSFP
Introduction: Balanced steady-state free precession (bSSFP) imaging offers a very high signal-to-noise ratio (SNR) and T2/T1-weighted image contrast useful for bright-blood MRI and fast imaging applications (1). The sequence requires a very short TR to reduce steady-state artifacts originating from the heterogeneity of the static magnetic field, but may consequently result in prohibitively high...
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